Impact of Azadirachta indica Fruit Mucilage on particle size and swelling index in Central Composite Designed Acyclovir mucoadhesive microspheres

The drive of this exploration is to investigate the mucoadhesive assets A. indica (Azadirachta indica) fruit mucilage by incorporating it into microspheres with Acyclovir (AVR) as a model drug. study was performed check impact proportion on particle size and swelling index. Nine batches AVR were made varying proportions Polyacrylic acid 934P (AIFM). A central composite design expert software dependent variables (A. 934 P levels) index response. As part congeniality studies, examined for their physical constraints, contents, liberation. found be 35.2±0.3-48.1±0.6μm. In batch B-1, least sized compared larger in B-5. investigation that depended AIFM proportions. research discovered systematically released controlled manner entrapment efficacy, mucoadhesion, drug content, other constraints good. capable good stomach-specific delivery enhanced when prepared microspheres. Scanning electron microscopy reveals spherical fairly smooth surface.